“Search for the truth is the noblest occupation of man; its publication is a duty.” -Madame de Stael
2023
Z Xie, J Morris, SJ Mattingly, SR Sutaria, J Huang, MH Nantz and X-A Fu
Analysis of a Broad Range of Carbonyl Metabolites in Exhaled Breath by UHPLC-MS
Analytical Chemistry, 95, In Press.
PK Adhihetty, S Halder, JB Jasinski, X-A Fu and MH Nantz
Harnessing Cation-π Interactions of Metallated Gold Monolayer Protected Clusters to Detect Aromatic Volatile Organic Compounds
Talanta, 53, 123915.
2022
A Shaffie, A Soliman, A Eledkawy, X-A Fu, MH Nantz, G Giridharan, V van Berkel and A El-Baz
Lung Cancer Diagnosis System Based on Volatile Organic Compounds (VOCs) Profile Measured in Exhaled Breath.
Applied Sciences, 12, 7165.
S Halder, Z Xie, MH Nantz and X-A Fu
Integration of a Micro-preconcentrator with Solid-Phase Microextraction for Analysis of Trace Volatile Organic Compounds by Gas Chromatography–Mass Spectrometry
Journal of Chromatography A, 1673, 463083.
A Puri, F Ibrahim, AO Beringhs, C Isemann, P Zakrevsky, A Whittenburg, D Hargrove, T Kanai, RS Dillard, N de Val, MH Nantz, X Lu and BA Shapiro
Stealth Oxime Ether Lipid Vesicles Promote Delivery of Functional DsiRNA in Human Lung Cancer A549 Tumor Bearing Mouse Xenografts
Nanomedicine: Nanotechnology, Biology, and Medicine, 44, 102572.
SR Sutaria, SS Gori, JD Morris, Z Xie, X-A Fu and MH Nantz
Lipid Peroxidation Produces a Diverse Mixture of Saturated and Unsaturated Aldehydes in Exhaled Breath that can Serve as Biomarkers of Lung Cancer — A Review
Metabolites, 12, 561.
2021
X-A Fu, MH Nantz, M Bousamra and V van Berkel
Noninvasive Detection of Cancer Originating in Tissue Outside of the Lung Using Exhaled Breath
United States Patent No. 11,016,082
Issued: May 25, 2021
MV Malovichko, WT Abplanalp, SA McFall, BS Taylor, NS Wickramasinghe, ID Sithu, IN Zelko, S Uchida, BG Hill, SR Sutaria, MH Nantz, A Bhatnagar, DJ Conklin, TE O'Toole, and S Srivastava
Subclinical Markers of Cardiovascular Toxicity of Benzene Inhalation in Mice
Toxicology and Applied Pharmacology, 431, 115742.
SR Sutaria and MH Nantz
A Convenient Preparation of Muconaldehyde Using a One-Pot Acid-to-Aldehyde Reduction Protocol
Organic Preparations and Procedures International, 53, 488–492.
A Shaffie, A Soliman, X-A Fu, MH Nantz, G Giridharan, V van Berkel, HA Khalifeh, M Ghazal, A Elmaghraby and A El-Baz
A Novel Technology to Integrate Imagining and Clinical Markers for Non-Invasive Diagnosis of Lung Cancer
Scientific Reports, 11, 4597.
2020
Z Xie, MVR Raju, PK Adhihetty, X-A Fu and MH Nantz
Effect of Thiol Molecular Structure on the Sensitivity and Selectivity of Gold Nanoparticle-Based Chemiresistors Toward Carbonyl Compounds
Sensors, 20, 7024.
TR Sibakoti, JB Jasinski, MH Nantz and FP Zamborini
Iodine Activation: A General Method for Catalytic Enhancement of Thiolate Monolayer-Protected Metal Clusters
Nanoscale, 12, 12027–12037.
2019
J Satyavolu, SS Gori, MH Nantz, MVR Raju and CT Burns
Process for Isolating C5 Sugars from Biomass Hydrolyzate
United States Patent No. 10,407,453
Issued: September 10, 2019
MH Nantz and RJ Knipp
Nanoparticles for Drug Delivery
United States Patent No. 10,342,870
Issued: July 9, 2019
TR Sibakoti, CR Stinger, PK Adhihetty, FP Zamborini and MH Nantz
Tunable Aminooxy-Functionalized Monolayer-Protected Gold Clusters for Nonpolar and Aqueous Oximation Reactions
Particle and Particle Systems Characterization, 36, 1900093.
MA Ogunwale, RJ Knipp, CN Evrard, LM Thompson, MH Nantz and X-A Fu
The Influence of Beta-Ammonium Substitution on the Reaction Kinetics of Aminooxy Condensations with Aldehydes and Ketones
ChemPhysChem, 20, 815-822.
R Ebule, S Mudshinge, MH Nantz, MS Mashuta, GB Hammond and B Xu
A 5+1 Protic Acid-Assisted aza-Pummerer Approach for Synthesis of 4-Chloropiperidines From Homoallylic Amines
Journal of Organic Chemistry, 84, 3249-3259.
2018
M Li, Q Li, MH Nantz and X-A Fu
Analysis of Carbonyl Compounds in Ambient air in by a Microreactor Approach
ACS Omega, 3, 6764 - 6769.
DJ Conklin, MA Ogunwale, Y Chen, MH Nantz, X-A Fu, DW Riggs, P Lorkiewicz, A Bhatnagar and S Srivastava
Electronic Cigarette-Generated Aldehydes: The Contribution of e-Liquid Components to their formation and the Use of Urinary Aldehyde Metabolites as Biomarkers of Exposure
Aerosol Science and Technology, 52, 1219 - 1232.
Z Xie, MVR Raju, AC Stewart, MH Nantz and X-A Fu
Imparting Sensitivity and Selectivity to a Gold Nanoparticle Chemiresistor through Thiol monolayer Functionalization for Sensing Acetone
RSC Advances, 8, 35618 - 35624.
P Deng, RM Higashi, AN Lane, RC Bruntz, RC Sun, MVR Raju, MH Nantz, Z Qi, and TW-M Fan
Quantitative Profiling of Carbonyl Metabolites Directly in Crude Biological Extracts Using Chemoselective Tagging and nanoESI-FTMS
Analyst, 143, 311-322.
2017
MH Nantz and RJ Knipp
Nanoparticles for Drug Delivery
United States Patent No. 9,849,193
Issued: December 26, 2017
MA Ogunwale, Y Chen, WS Theis, MH Nantz, DJ Conklin and X-A Fu
A Novel Method of Nicotine Quantification in Electronic Cigarette Liquids and Aerosols
Analytical Methods, 9, 4261-4266.
X-A Fu, MH Nantz and M Bousamra
Noninvasive Detection of Lung Cancer
United States Patent No. 9,638,965
Issued: May 2, 2017
(Textbook) GS Zweifel, MH Nantz and P Somfai
Modern Organic Synthesis: An Introduction, 2nd Edition; Wiley: New York
ISBN: 978-1-119-08653-6 (416 pages).
MA Ogunwale, M Li, MVR Raju, Y Chen, MH Nantz, DJ Conklin and X-A Fu
Aldehyde Detection in Electronic Cigarette Aerosols
ACS Omega, 2, 1207-1214.
2016
SK Biladeau, WN Richmond, S Laulhé and MH Nantz
Isotopically Coded N-Methoxy Amide Reagents for GC-MS Profiling of Carbonyl Compounds via Mass Spectral Tag Generation
Analytical Methods, 8, 3704-3710.
MG O’Toole, PA Soucy, R Chauhan, MVR Raju, DN Patel, BM Nunn, MA Keynton, WD Ehringer, MH Nantz, RS Keynton and AS Gobin
Release-Modulated Antioxidant Activity of a Composite Curcumin-Chitosan Polymer
Biomacromolecules, 17, 1253-1260.
2015
K Gupta, SJ Mattingly, RJ Knipp, KA Afonin, M Viard, JT Bergman, M Stepler, MH Nantz, A Puri and BA Shapiro
Oxime Ether Lipids Containing Hydroxylated Head Groups Are More Superior siRNA Delivery Agents Than Their Nonhydroxylated Counterparts
Nanomedicine, 10, 2805-2828.
JG Hecker and MH Nantz
Methods and Models for Rapid, Widespread Delivery of Genetic Material to the CNS Using Non-Viral, Cationic Lipid-Mediated Vectors
United States Patent No. 9,149,543
Issued: October 6, 2015
SS Gori, MVR Raju, DA Fonseca, J Satyavolu, CT Burns and MH Nantz
Isolation of C5-Sugars from the Hemicellulose-Rich Hydrolyzate of Distillers Dried Grains
ACS Sustainable Chemistry & Engineering, 3, 2452-2457.
M Li, D Yang, G Brock, RJ Knipp, M Bousamra, MH Nantz and X-A Fu
Breath Carbonyl Compounds as Biomarkers of Lung Cancer
Lung Cancer, 90, 92-97.
RJ Knipp, M Li, X-A Fu and MH Nantz
A Versatile Probe for Chemoselective Capture and Analysis of Carbonyl Compounds in Exhaled Breath
Analytical Methods, 7, 6027-6033.
SJ Mattingly, MG O’Toole, KT James, GJ Clark and MH Nantz
Magnetic Nanoparticle–Supported Lipid Bilayers for Drug Delivery
Langmuir, 31, 3326-3332.
AN Lane, S Arumugam, PK Lorkiewicz, RM Higashi, S Laulhé, MH Nantz, HNB Moseley and TW-M Fan
Chemoselective Detection and Discrimination of Carbonyl-Containing Compounds in Metabolite Mixtures by 1H-Detected 15N Nuclear Magnetic Resonance
Magnetic Resonance in Chemistry, 53, 337-343.
ACG Grodzki, B Poola, N Pasupuleti, MH Nantz, PJ Lein and FA Gorin
A Novel Carboline Derivative Inhibits Nitric Oxide Formation in Macrophages Independent of Effects on TNF and IL-1 Expression
Journal of Pharmacology and Experimental Therapeutics, 352, 438-447.
2014
KA Kang and MH Nantz
Site Specific Fluorescence and Contrast Marker for Same
United States Patent No. 8,758,727
Issued: June 24, 2014
M Bousamra, E Schumer, M Li, RJ Knipp, MH Nantz, VH van Berkel and X-A Fu
Quantitative Analysis of Exhaled Carbonyl Compounds Distinguishes Benign From Malignant Pulmonary Disease
Journal of Thoracic and Cardiovascular Surgery, 148, 1074-1081.
SS Gori, P Lorkiewicz, DS Ehringer, AC Belshoff, RM Higashi, TW-M Fan and MH Nantz
Profiling Thiol Metabolites and Quantification of Cellular Glutathione using FT-ICR-MS Spectrometry
Analytical and Bioanalytical Chemistry, 406, 4371-4379.
RJ Knipp, R Estrada, P Sethu and MH Nantz
Thermally Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates
Tetrahedron, 70, 3422-3429.
X-A Fu, RM Higashi and MH Nantz
Pre-Concentrator and Method of Using the Same
United States Patent No. 8,663,581
Issued: March 4, 2014
X-A Fu, M Li, RJ Knipp, MH Nantz and M Bousamra
Noninvasive Detection of Lung Cancer Using Exhaled Breath
Cancer Medicine, 5, 174-181.
2013
FA Gorin and MH Nantz
Inhibitors of Intracellular Urokinase Plasminogen Activator and Methods of Use Thereof
United States Patent No. 8,546,322
Issued: October 1, 2013
S Laulhé, TE Geers, X Shi, X Zhang and MH Nantz
Electron Ionization-Induced Release of Coded Isotopic Reporter Ions in an m/z Zone of Minimal Interference for Quantifiable Multiplexed GC-MS Analyses
Analytical Methods, 5, 4701-4706.
M Li, S Biswas, MH Nantz, RM Higashi and X-A Fu
A Microfabricated Preconcentration Device for Breath Analysis
Sensors and Actuators B: Chemical, 180, 130-136.
2012
SJ Mattingly, T Xu, MH Nantz, RM Higashi and TW-M Fan
A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts
Metabolomics, 8, 989-996.
S Laulhé, SS Gori and MH Nantz
A Chemoselective, One-Pot Transformation of Aldehydes to Nitriles
Journal of Organic Chemistry, 77, 9334-9337.
S Laulhé, B Bogdanov, LM Johannes, O Gutierrez, GJ Harrison, DJ Tantillo,
X Zhang and MH Nantz
Fragmentation of Oxime and Silyl-Oxime Ether Odd-Electron Positive Ions by the McLafferty Rearrangement: New Insights on Structural Factors that Promote alpha-beta Fragmentation
Journal of Mass Spectrometry, 47, 676-686.
KA Kang, J Wang, MG O'Toole, MH Nantz, JD Moore, S Laulhé and S Achilefu
Sensitivity Enhancement of NIR Fluorescence Contrast Agent Utilizing Gold Nanoparticles
Advances in Experimental Medicine and Biology, 737, 285-291.
AP Massey, WR Harley, N Pasupuleti, FA Gorin and MH Nantz
2-Amidino Analogs of Glycine-Amiloride Conjugates: Inhibitors of Urokinase-type Plasminogen Activator
Bioorganic & Medicinal Chemistry Letters, 22, 2635-2639.
J Wang, JD Moore, S Laulhé, MH Nantz, S Achilefu and KA Kang
Fluorophore-Gold Nanoparticle Complex for Sensitive Optical Biosensing and Imaging
Nanotechnology, 23, 095501 (13pp).
M Li, S Biswas, MH Nantz, RM Higashi and X-A Fu
Preconcentration and Analysis of Trace Volatile Carbonyl Compounds
Analytical Chemistry, 84, 1288-1293.
2011
S Yellayi, B Hilliard, M Ghazanfar, A Tsingalia, MH Nantz, L Bollinger, F de Kok-Mercado and JG Hecker
A Single Intrathecal Injection of DNA and Asymmetric Cationic Lipid as Lipoplexes Ameliorates Experimental Autoimmune Encephalomyelitis
Molecular Pharmaceutics, 8, 1980-1984.
S Biswas, RJ Knipp, LE Gordon, GJ Clark and MH Nantz
Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids
ChemMedChem, 6, 2063-2069.
S Laulhé and MH Nantz
An Improved Preparation of O-Diphenylphosphinylhydroxylamine
Organic Preparations & Procedures, Int., 43, 475-476.
X-A Fu, M Li, S Biswas, MH Nantz and RM Higashi
A Novel Microreactor Approach for Analysis of Ketones and Aldehydes in Breath
Analyst, 136, 4662-4666.
J Wang, S Achilefu, MH Nantz and KA Kang
Gold Nanoparticle-Fluorophore Complex for Conditionally Fluorescing Signal Mediator
Analytica Chimica Acta, 695, 96-104.
S Biswas, LE Gordon, GJ Clark, and MH Nantz
Click Assembly of Magnetic Nanovectors for Gene Delivery
Biomaterials, 32, 2683-2688.
J Wang, MG O'Toole, AP Massey, S Biswas, MH Nantz, S Achilefu and KA Kang
Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticles.
Advances in Experimental Medicine and Biology, 701, 149-154.
FA Gorin and MH Nantz
Amino Acid and Peptide Conjugates of Amiloride and Methods of Use Thereof
United States Patent No. 7,863,415
Issued: January 4, 2011
2010
WR Harley, CL Floyd, TN Dunn, X-D Zhang, T-Y Chen, M Hegde, H Palandoken, MH Nantz, L Leon, KL Carraway III, BG Lyeth and FA Gorin
Dual Inhibition of Sodium-Mediated Proton and Calcium Transport Efflux Produces Caspase-Independent Cell Death in Malignant Gliomas
Brain Research, 1363, 159-169.
MH Nantz, CW Dicus, B Hilliard, S Yellayi, S Zou and JG Hecker
The Benefit of Hydrophobic Domain Asymmetry on the Efficacy of Transfection as Measured by In Vivo Imaging
Molecular Pharmaceutics, 7, 786-794.
S Zou, KA Scarfo, MH Nantz and JG Hecker
Lipid-Mediated Delivery of RNA is More Efficient Than Delivery of DNA in Non-Dividing Cells
International Journal of Pharmaceutics, 389, 232-243.
S Biswas, X Huang, WR Badger and MH Nantz
Nucleophilic Cationization Reagents
Tetrahendron Letters, 51, 1727-1729.
2009
J Wang, MH Nantz, S Achilefu and KA Kang
FRET-Like Fluorophore-Nanoparticle Complex for Highly Specific Cancer Localization
Advances in Experimental Medicine and Biology, 662, 407-414.
(Textbook) H Palandoken, MH Nantz and GS Zweifel
Problems in Organic Synthesis, WH Freeman & Co.: New York; ISBN: 1-4292-5592-7 (305 pages).
MT Nyunt, CW Dicus, Y.-Y Cui, MC Yappert, TR Huser, MH Nantz and J Wu
Physico-Chemical Characterization of Polylipid Nanoparticles for Gene Delivery to the Liver
Bioconjugate Chemistry, 20, 2047-2054.
2008
L Al-Nakkash, MF Springsteel, MJ Kurth and MH Nantz
Activation of CFTR by UCCF-029 and Genistein
Bioorganic & Medicinal Chemistry Letters, 18, 3874-3877.
JG Hecker, GO Berger, KA Scarfo, S Zou and MH Nantz
A Flexible Method for the Conjugation of Aminooxy Ligands to Pre-Formed Complexes Nucleic Acids and Lipids
ChemMedChem, 3, 1356-1361.
B Poola, W Choung and MH Nantz
A Mild, Catalyst-Free Synthesis of 2-Aminopyridines
Tetrahedron, 64, 10798-10801.
ES Hauck, S Zou, K Scarfo, MH Nantz and JG Hecker
Whole Animal In Vivo Imaging After Transient Nonviral Gene Delivery to the Rat Central Nervous System
Molecular Therapy, 16, 1857-1864.
2006
S-Q He, Y-H Zhang, SK Venugopal, CW Dicus, RV Perez, R Ramsamooj, MH Nantz, MA Zern and J Wu
Delivery of Antioxidative Enzyme Genes Protects Against Ischemia/Reperfusion-Induced Liver Injury in Mice
Liver Transplantation, 12, 1869-1879.
YF Suen, H Hope, MH Nantz, MJ Haddadin and MJ Kurth
Transannular Anti-Michael Addition: Formation of 4H-Pyrazolo[5,1-c]thiazines
Tetrahedron Letters, 47, 7893-7896.
CW Dicus and MH Nantz
Synthesis of a Heterobifunctional PEG Spacer Terminated with Aminooxy and Bromide Functionality
Synlett 17, 2821-2823.
R Rieger, PSC Leung, MR Jeddeloh, MJ Kurth, MH Nantz, KS Lam, D Barsky, AA Ansari, RL Coppel, IR Mackay and ME Gershwin
Identification of 2-Nonynoic Acid, a Cosmetic Component, as a Potential Trigger of Primary Biliary Cirrhosis
Journal of Autoimmunity, 27, 7-16.
(Textbook) MH Nantz, H Palandoken and GS Zweifel
Solutions Manual for Modern Organic Synthesis, WH Freeman & Co.: New York; ISBN: 0-7167-7494-1 (218 pages).
(Textbook) GS Zweifel and MH Nantz
Modern Organic Synthesis: An Introduction, WH Freeman & Co.: New York; ISBN: 0-7167-7266-3 (504 pages).
YF Suen, L Robins, B Yang, AS Verkman, MH Nantz and MJ Kurth
Sulfamoyl-4-oxoquinoline-3-carboxamides: Novel Potentiators of Defective ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Gating
Bioorganic & Medicinal Chemistry Letters, 16, 537-540.
2005
YF Suen, H Hope, MH Nantz, MJ Haddadin and MJ Kurth
A Novel Route to Fully Substituted 1H-Pyrazoles
Journal of Organic Chemistry, 70, 8468-8471.
H Palandoken, CM Bocian, MR McCombs and MH Nantz
A Facile Synthesis of (tert-Alkoxy)amines
Tetrahedron Letters, 46, 6667-6669.
N Pedemonte, ND Sonawane, A Taddei, J Hu, O Zegarra-Moran, YF Suen, L Robins, CW Dicus, D Willenbring, MH Nantz, MJ Kurth, LJV Galietta and AS Verkman Phenylglycine and Sulfonamide Correctors of Defective ΔF508- and G551D-CFTR Chloride-Channel Gating
Molecular Pharmacology, 67, 1797-1807.
K Amano, PSC Leung, R Rieger, C Quan, X Wang, J Marik, YF Suen, MJ Kurth, MH Nantz, AA Ansari, KS Lam, M Zeniya, E Matsuura, RL Coppel and ME Gershwin Chemical Xenobiotics and Mitochondrial Autoantigens in Primary Biliary Cirrhosis: Identification of Antibodies against a Common Environmental, Cosmetic, and Food Additive, 2-Octynoic Acid
Journal of Immunology, 174, 5874-5883.
CW Dicus, D Willenbring and MH Nantz
Synthesis of 13C1-Pinonaldehyde
Journal of Labelled Compounds and Radiopharmaceuticals, 48, 223-229.
H Palandoken, K By, M Hegde, WR Harley, FA Gorin and MH Nantz
Amiloride Peptide Conjugates: Prodrugs for Sodium-Proton Exchange Inhibition
Journal of Pharmacology and Experimental Therapuetics, 312, 961-967.
2004
JT Sanderson, J Hordijk, MS Denison, MF Springsteel, MH Nantz and M van den Berg
Induction and Inhibition of Aromatase (CYP19) Activity by Natural and Synthetic Flavonoid Compounds in H295R Human Adrenocortical Carcinoma Cells
Toxicological Sciences, 82, 70-79.
K Amano, PSC Leung, Q Xu, J Marik, C Quan, MJ Kurth, MH Nantz, AA Ansari, KS Lam, M Zeniya, RL Coppel and ME Gershwin
Xenobiotic-Induced Loss of Tolerance in Rabbits to the Mitochondrial Autoantigen of Primary Biliary Cirrhosis is Reversible
Journal of Immunology, 172, 6444-6452.
B Zhao, S Nagy, J Rogers, MH Nantz, MJ Kurth, MF Springsteel and MS Denison
Identification and Analysis of Novel Flavonoid Agonists and Antagonists for the Ah and Estrogen Receptor
Organohalogen Compounds, 66,2960-2965.
J Wu, L Liu, RD Yen, A Catana, MH Nantz and MA Zern
Liposome-Mediated Extracellular Superoxide Dismutase Gene Delivery Protects Against Acute Liver Injury in Mice
Hetaptology, 40, 195-204.
K By and MH Nantz
Dioxazocinium Ortho Esters: A Class of Highly pH-Vulnerable Amphiphiles
Angewandte Chemie International Ed., 43, 1117-1120.
2003
SFA Bruggraber, PSC Leung, K Amano, C Quan, MJ Kurth, MH Nantz, GD Benson, J Van de Water, V Luketic, TE Roche, AA Ansari, RL Coppel and ME Gershwin
Autoreactivity to Lipoate and a Conjugated Form of Lipoate in Primary Biliary Cirrhosis
Gastroenterology, 125, 1705-1713.
C Selmi, DL Balkwill, P Invernizzi, AA Ansari, RL Coppel, M Podda, PS Leung, TP Kenny, J Van de Water, MH Nantz, MJ Kurth and ME Gershwin
Patients with Primary Biliary Cirrhosis React Against a Ubiquitous Xenobiotic Metabolizing Bacterium
Hepatology, 38, 1250-1257.
DS Baston, SR Nagy, MH Nantz, MJ Kurth, MF Springsteel and MS Denison
Identification of Novel Agonists and Antagonists of the Ah Receptor Signal Transduction Pathway
Organohalogen Compounds, 65, 142-145.
D-H Han, B Zhao, DS Baston, MF Springsteel, MJ Kurth, MH Nantz and MS Denison
Identification and Characterization of Novel Flavone Agonists of the Ah Receptor
Organohalogen Compounds, 65, 126-129.
B Zhao, SR Nagy, DS Baston, D-H Han, MH Nantz, MJ Kurth, MF Springsteel and MS Denison
Screening and Analysis of Novel Naphthoflavone Ligands for the Ah Receptor
Organohalogen Compounds, 65, 102-105.
PA Kelly, GO Berger, JK Wyatt and MH Nantz
Synthesis of [Ethylene-1-(h5-4, 5, 6, 7-tetrahydro-1-indenyl)-2-(h5-4’, 5’, 6’, 7’-tetrahydro-2’-indenyl)] titanium Dichloride, the Elusive Isomer of the Brintzinger-type ansa-Titanocenes
Journal of Organic Chemistry, 68, 8447-8452.
MF Springsteel, LJV Galietta, T Ma, K By, GO Berger, H Yang, CW Dicus, W Choung, C Quan, AA Shelat, RK Guy, AS Verkman, MJ Kurth and MH Nantz
Benzoflavone Activators of the Cystic Fibrosis Transmembrane Conductance Regulator: Towards a Pharmacophore Model for the Nucleotide-Binding Domain
Bioorganic & Medicinal Chemistry, 11, 4113-4120.
E Caci, C Folli, O Zegarra-Moran, T Ma, MF Springsteel, RE Sammelson, MH Nantz, MJ Kurth, AS Verkman and LJV Galietta
CFTR Activation in Human Bronchial Epithelial Cells By Novel Benzoflavone and Benzimidazolone Compounds Identified By High-Throughput Screening
American Journal of Physiology — Lung Cellular and Molecular Physiology, 285, L180-L188.
PSC Leung, C Quan, O Park, J Van de Water, MJ Kurth, MH Nantz, AA Ansari, RL Coppel, KS Lam and ME Gershwin
Immunization With a Xenobiotic 6-Bromohexanoate Bovine Serum Albumin Conjugate Induces Antimitochondrial Antibodies
Journal of Immunology, 170, 5326-5332.
CW Dicus, KJ Burnham, MJ Charles and MH Nantz
Synthesis of 13C3-Hydroxyacetone
Journal of Labelled Compounds and Radiopharmaceuticals, 46, 793-798.
EJ Niedzinski, DC Olson, YJ Chen, JA Udove, MH Nantz, HC Tseng, JL Bolaffi and MJ Bennett
Zinc Enhancement of Nonviral Salivary Gland Transfection
Molecular Therapy, 7, 396-400.
DM Anderson, LL Hall, AR Ayyalapu, VR Irion, MH Nantz and JG Hecker
Stability of mRNA/Cationic Lipid Lipoplexes in Human and Rat Cerebro-spinal Fluid: Methods and Evidence for Non-Viral mRNA Gene Delivery to the Central Nervous System
Human Gene Therapy, 14, 191-202.
MR Lashley, CW Dicus, K Brown and MH Nantz
Synthesis of a-Hydroxytamoxifen and Its 4-Hydroxy Analog
Organic Preparations & Procedures International, 35, 231-238.
L Liu, MA Zern, ME Lizarzaburu, MH Nantz and J Wu
Poly(Cationic Lipid)-Mediated in vivo Gene Delivery to Mouse Liver
Gene Therapy, 10, 180-187.
2002
Bennett, M. J.; Nantz, M. H.; Rothman, S.
Method for Nucleic Acid Transfection of Cells
United States Patent No. 6,372,722
Issued: April 16, 2002
MM Olmstead, K By and MH Nantz
A Long Thin Molecule, 2,6-Dimethyl-6 tetradecyl-2-tetradecyloxy-1,3,6
dioxazocan-6 ium Iodide
Acta Crystallographica E58, o1323-o1324.
MR Lashley, EJ Niedzinski, JM Rogers, MS Denison and MH Nantz
Synthesis and Estrogen Receptor Affinity of a 4-Hydroxytamoxifen–Labeled Ligand for Diagnostic Imaging
Bioorganic & Medicinal Chemistry, 10, 4075-4082.
EJ Niedzinski, SK Fujii, ME Lizarzaburu, JG Hecker and MH Nantz
A Versatile Linker for Non-Toxic Polyamine-Mediated DNA Transfection.
Molecular Therapy, 6, 279-286.
J Wu, MH Nantz and MA Zern
Targeting Hepatocytes for Drug and Gene Delivery: Emerging Novel Approaches and Applications.
Fontiers in Bioscience, 7, D717-D725.
2001
Nantz, M. H.; Zhu, J.
Ortho Ester Lipids
United States Patent No. 6,200,599
Issued: March 13, 2001
Nantz, M. H.; Aberle, A. M.
Pentaerythritol Lipid Derivatives (Divisional)
United States Patent No. 6,316,421
Issued: November 13, 2001
SA Long, C Quan, J Van de Water, MH Nantz, MJ Kurth, D Barsky, ME Colvin, KS Lam, RL Coppel, A Ansari and ME Gershwin
Immunoreactivity of Organic Mimeotopes of the E2 Component of Pyruvate Dehydrogenase: Connecting Xenobiotics with Primary Biliary Cirrhosis
Journal of Immunology, 167, 2956-2963.
KA Campbell, MR Lashley, JK Wyatt, MH Nantz and RD Britt
Dual-Mode EPR Study of Mn(III) Salen and the Mn(III) Salen-Catalyzed Epoxidation of cis-b-Methylstyrene
Journal of the American Chemical Society, 123, 5710-5719.
LVJ Galietta, MF Springsteel, M Eda, EJ Niedzinski, K By, MJ Haddadin, MJ Kurth, MH Nantz and AS Verkman
Novel CFTR Chloride Channel Activators Identified By Screening of Combinatorial Libraries Based on Flavone and Benzoquinolizinium Lead Compounds
Journal of Biological Chemistry, 276, 19723-19728.
EJ Niedzinski, MR Lashley and MH Nantz
On the Synthesis and Reactivity of 1-Benzyl-2-arylquinoline-4-thiones
Heterocycles, 55, 623-627.
C Alonso, MM Olmstead, MH Nantz and MJ Kurth
Competitive Intramolecular Nucleophilic Aromatic Substitution: A New Route to Coumarins
Journal of the Chemical Society, Chemical Communications, 639-640.
J Wu, ME Lizarzaburu, MJ Kurth, H Wege, MA Zern and MH Nantz
Cationic Lipid Polymerization as a Novel Approach to Improve Lipoplex Stability, Toxicity and Transfection Activity
Bioconjugate Chemistry, 12, 251-257.
K By, PA Kelly, MJ Kurth, MM Olmstead and MH Nantz
Synthesis of a C(4)-C(9) Eleutheside Template From D-Glucal
Tetrahedron, 57, 1183-1187.
2000
Nantz, M. H.; Aberle, A. M.
Pentaerythritol Lipid Derivatives
United States Patent No. 6,043,390
Issued: March 28, 2000
B Illek, ME Lizarzaburu, V Lee, MH Nantz, MJ Kurth and H Fischer
Structural Determinants for Activation and Block of CFTR-Mediated Chloride Currents by Apigenin
American Journal of Physiology and Cell Physiology, 279, 1838-1846.
M Eda, MJ Kurth and MH Nantz
The Solid-Phase Zincke Reaction: Preparation of w-Hydroxy Pyridinium Salts in the Search for CFTR Activation
Journal of Organic Chemistry, 65, 5131-5135.
EJ Niedzinski, MJ Bennett, DC Olson and MH Nantz
Gastroprotection of DNA with a Synthetic Cholic Acid Analog
Lipids, 35, 721-727.
C Alonso, MH Nantz and MJ Kurth
b-Dimethylphenylsilylethyl Esters: A Linker for Solid-Phase Chemistry
Tetrahedron Letters, 41, 5617-5622.
P Kim, MM Olmstead, MH Nantz and MJ Kurth
Knoevenagel Condensations of b-Hemiacetyl Esters
Tetrahedron Letters, 41, 4029-4032.
P Kim, MH Nantz, MJ Kurth and MM Olmstead
Intramolecular Diels-Alder Reactions of Decatrienoates: Remote Stereocontrol and Conformational Activation
Organic Letters, 2, 1831-1834.
MR Lashley and MH Nantz
Synthesis of Lipidic Tamoxifen
Tetrahedron Letters, 41, 3295-3298.
J Zhu, RJ Munn and MH Nantz
Self-Cleaving Ortho Ester Lipids: A New Class of pH-Vulnerable Amphiphiles
Journal of the American Chemical Society, 122, 2645-2646.
1999
Nantz, M. H.; Bennett, M. J.; Balasubramaniam, R. P.
Polyfunctional Cationic Cytofectins
United States Patent No. 5,869,715
Issued: February 9, 1999
Nantz, M. H.; Bennett, M. J.; Malone, R. W.
Cationic Transport Reagents (CIP)
United States Patent No. 5,892,071
Issued: April 6, 1999
Nantz, M. H.; Bennett, M. J.; Balasubramaniam, R. P.; Aberle, A. M.; Malone, R. W.
Polyfunctional Cationic Cytofectins, Formulations and Methods for Generating Active Cytofectin: Polynucleotide Transfection Complexes
United States Patent No. 5,925,623
Issued: July 20, 1999
Nantz, M. H.; Bennett, M. J.; Balasubramaniam, R. P.; Aberle, A. M.; Malone, R. W.
Polyfunctional Cationic Cytofectins, Formulations and Methods for Generating Active Cytofectin: Polynucleotide Transfection Complexes (CIP)
United States Patent No. 5,824,812
Issued: October 20, 1998
Palandoken, H.; Wyatt, J. K.; Hitchcock, S. R.; Olmstead, M. M.; Nantz, M. H.
Reductive Dehydroxy Coupling of 2-(Hydroxymethyl)indenes to Prepare Ethylene-Bridged Bis(2-indenyl) ansa-Titanocenes
Journal of Organometallic Chemistry, 579, 338-347.
Moss, D. K.; Spence, J. D.; Nantz, M. H.
The Effects of Propargylic Substitution and Annelation on the Cycloaromatization of a Bicyclo[7.3.1] Enediyne
Journal of Organic Chemistry, 64, 4339-4343.
Lizarzaburu, M. E.; Jones, R. M.; Nantz, M. H.; Kurth, M. J.
Mutligram Synthesis of Dimyristoyl Pentaerythritol
Organic Preparations and Procedures Intl., 31, 440-442.
Lizarzaburu, M. E.; Kurth, M. J.; Nantz, M. H.
A Versatile Synthesis of Tetraester Polyamine Lipids for Gene Transfection
Tetrahedron Letters, 40, 8985-8988.
1998
Nantz, M. H.; Bennett, M. J.; Malone, R. W.
Cationic Transport Reagents (Divisional Application)
United States Patent No. 5,744,625
Issued: April 28, 1998
Nantz, M. H.; Moss, D. K.; Spence, J. D.; Olmstead, M. M.
Actuating Cycloaromatization of a Bicyclo[7.3.1] Enediyne by Annelation, an Example of Inverse Dependence on Bridge Hybridization
Angewandte Chemie, Intl. Ed., 37, 470-473.
Aberle, A. M.; Tablin, F.; Zhu, J.; Walker, N. J.; Gruenert, D. C.; Nantz, M. H.
A Novel Tetraester Construct That Reduces Cationic Lipid-Associated Cytotoxicity. Implications for the Onset of Cytotoxicity
Biochemistry, 37, 6533-6540.
Moss, D. K.; Olmstead, M. M.; Nantz, M. H.
Aluminum-Mediated 1,2-Alkyl Migration Resulting From Hydrocyanation of an alpha-Epoxy Ketone
Journal of Organic Chemistry, 63, 5259-5261.
Nantz, M. H.; Li, L.; Zhu, J.; Aho-Sharon, K. L.; Lim, D.; Erickson, K. L.
Inductive Electron-Withdrawal From Ammonium Ion Headgroups of Cationic Lipids and the Influence on DNA Transfection
Biochim. Biophys. Acta, 1394, 219-223.
1997
Balasubramaniam, R. P.; Moss, D. K.; Wyatt, J. K.; Spence, J. D.; Gee, A. H.; Nantz, M. H.
Quaternary Centers Via Regioselective Methylation-Ring Opening of 3,3-Disubstituted 2,3-Epoxy Alcohols. Synthesis of Chiral Quaternary Fragments for Assembly of Briaran Diterpenes
Tetrahedron, 53, 7429-7444.
Wisner, E. R.; Aho-Sharon, K. L.; Bennett, M. J.; Penn, S. G.; Lebrilla, C. B.; Nantz, M. H.
A Modular Lymphographic Magnetic Resonance Imaging Contrast Agent: Contrast Enhancement with DNA Transfection Potential
Journal of Medicinal Chemistry, 40, 3992-3996.
Bennett, M. J.; Aberle, A. M.; Balasubramaniam, R. P.; Malone, J. G.; Malone, R. W.; Nantz, M. H.
Cationic Lipid-Mediated Gene Delivery to Murine Lung: Correlation of Lipid Hydration With In Vivo Transfection Activity
Journal of Medicinal Chemistry, 40, 4069-4078.
1996
Nantz, M. H.; Bennett, M. J.; Malone, R. W.
Cationic Transport Reagents
United States Patent No. 5,527,928
Issued: June 18, 1996
Aberle, A. M.; Bennett, M. J.; Malone, R. W.; Nantz, M. H.
The Counterion Influence on Cationic Lipid-Mediated Transfection of Plasmid DNA
Biochim. Biophys. Acta, 1299, 281-283.
Balasubramaniam, R. P.; Bennett, M. J.; Aberle, A. M.; Malone, J. G.; Nantz, M. H.; Malone, R. W.
Structural and Functional Analysis of Cationic Transfection Lipids: The Hydrophobic Domain
Gene Therapy, 3, 163-172.
Spence, J. D.; Wyatt, J. K.; Bender, D. M.; Moss, D. K.; Nantz, M. H.
Stereogenic Propargylic Centers Via Base-Mediated Terminal Allene Isomerization
Journal of Organic Chemistry, 61, 4014-4021.
Olmstead, M. M.; Hitchcock, S. R.; Nantz, M. H.
Cyclohexane-Linked Indenyl Rings in 5,8-Bis(trimethylsilyl)-6,7-dihydroindeno[2,1c]-fluorene
Acta Crystallographica, C52, 1523.
Bennett, M. J.; Aberle, A. M.; Balasubramaniam, R. P.; Malone, J. G.; Nantz, M. H.; Malone, R. W.
Considerations for the Design of Improved Cationic Amphiphile-Based Transfection Reagents
Journal of Liposome Research, 6, 545.
Palandoken, H.; McMillen, W. T.; Nantz, M. H.
An Improved Synthesis of 2-(Hydroxymethyl)indene
Organic Preparations and Procedures Intl., 28, 702-704.
Freedland, S. J.; Malone, R. W.; Borchers, H. M.; Zadourian, Z.; Malone, J. G.; Bennett, M. J.; Nantz, M. H.; Juan-Hua, L.; Gummerlock, P. H.; Erickson, K. L.
Toxicity of Cationic Lipid-Ribozyme in Human Prostate Tumor Cells Can Mimic Ribozyme Activity.
Biochemical and Molecular Medicine, 59, 144-153.
1995
Bennett, M. J.; Nantz, M. H.; Balasubramaniam, R. P.; Gruenert, D. C.; Malone, R. W.
Cholesterol Enhances Cationic Liposome-Mediated DNA Transfection of Human Respiratory Epithelial Cells
Bioscience Reports, 15, 47.
Bennett, M. J.; Malone, R. W.; Nantz, M. H.
A Flexible Approach to Synthetic Lipid Ammonium Salts for Polynucleotide Transfection
Tetrahedron Letters, 36: 2207-2210.
Spence, J. D.; Lowrie, L. E.; Nantz, M. H.
Cyclobutene Formation Accompanying an Intramolecular Lewis Acid-Promoted Spirocyclization of a Propargylic Silane
Tetrahedron Letters, 36: 5499-5502.
Hitchcock, S. R.; Situ, J. J.; Covel, J. A.; Olmstead, M. M.; Nantz, M. H.
Synthesis of ansa-Titanocenes From 1,2-Bis(2-indenyl)ethane and Structural Comparisons in the Catalytic Epoxidation of Unfunctionalized Alkenes
Organometallics, 14: 3732-3740.
1994 - 1984
Parkin, S.; Hitchcock, S. R.; Hope, H.; Nantz, M. H.
2,2'-Ethylenebis(indenyl)TiCl2
Acta Crystallographica, C50, 169-171 (1994).
Nantz, M. H.; Bender, D. M.; Janaki, S.
A Convenient Terminal Allene Synthesis from Propargylic Acetates
Synthesis, 577-578 (1993).
Sutton, S. C.; Nantz, M. H.; Parkin, S.
Synthesis of ansa-Titanocenes via a Double-Skattebøl Rearrangement
Organometallics, 12, 2248-2257 (1993).
Nantz, M. H.; Hitchcock, S. R.; Sutton, S. C.; Smith, M. D.
A Disulfone-Based Approach to ansa-Titanocenes: Synthesis of (Ethylenebis(2-indenyl))titanium Dichloride
Organometallics, 12, 5012-5015 (1993).
Sutton, S. C.; Nantz, M. H.; Hitchcock, S. R.
Preparation and Optical Resolution of DL-2,3-Dimethylsuccinic Acid
Organic Preparations and Procedures Intl., 24, 39-43 (1992).
Nantz, M. H.; Lee, D. A.; Bender, D. M.; Roohi, A. H.
An Enantioselective Synthesis of Vicinal Diamines
Journal of Organic Chemistry, 57, 6653-6657 (1992).
Kageyama, M.; Tamura, T.; Nantz, M. H.; Roberts, J. C.; Somfai, P.; Whritenour, D. C.; Masamune, S.
Synthesis of Bryostatin 7
Journal of the American Chemical Society, 112, 7407-7408 (1990).
Pan, Y.; Hutchinson, D. K.; Nantz, M. H.; Fuchs, P. L.
SN2' Additions of Cuprates to Sulfone and Ester Polarized Cyclopentenylic Systems
Tetrahedron, 45, 467-478 (1989).
Blanchette, M. A.; Malamus, M. S.; Nantz, M. H.; Roberts, J. C.; Somfai, P.; Whritenour, D. C.; Masamune, S.; Kageyama, M.; Tamura, T.
Synthesis of Bryostatins. 1. Construction of the C(1)-C(16) Fragment
Journal of Organic Chemistry, 54, 2817-2825 (1989).
Duplantier, A. J.; Nantz, M. H.; Roberts, J. C.; Short, R. P.; Somfai, P.; Masamune, S.
Triple Asymmetric Synthesis for Fragment Assembly: Validity of Approximate Multiplicativity of the Three Diastereofacial Selectivities
Tetrahedron Letters, 30, 7357-7360 (1989).
Nantz, M. H.; Fuchs, P. L.
Efficient Generation and Use of 3-Carboalkoxycyclopentan-dienone as a Diels-Alder Dienophile
Journal of Organic Chemistry, 52, 5298-5299 (1987).
Nantz, M. H.; Radisson, X.; Fuchs, P. L.
Efficient 4 +1 Syntheses of Highly Functionalized Cyclopentenes
Synthetic Communications, 17, 55-69 (1987).
Nantz, M. H.; Fuchs, P. L.
Cycloaromatization Reactions of Methyl 4-Carbomethoxy-5-methoxy-penta-2,4-dienoate
Synthetic Communications, 17, 761-771 (1987).
Frisbee, A. R.; Nantz, M. H.; Kramer, G. W.; Fuchs, P. L.
Robotic Orchestration of Organic Reactions Yield Optimization via an Automated System with Operator-Specified Reaction Sequences
Journal of the American Chemical Society, 106, 7143-7145 (1984).