Publications

“Search for the truth is the noblest occupation of man; its publication is a duty.” -Madame de Stael


2019


J Satyavolu, SS Gori, MH Nantz, MVR Raju and CT Burns

Process for Isolating C5 Sugars from Biomass Hydrolyzate

United States Patent No. 10,407,453

Issued: September 10, 2019


MH Nantz and RJ Knipp

Nanoparticles for Drug Delivery

United States Patent No. 10,342,870

Issued: July 9, 2019


TR Sibakoti, CR Stinger, PK Adhihetty, FP Zamborini and MH Nantz

Tunable Aminooxy-Functionalized Monolayer-Protected Gold Clusters for Nonpolar and Aqueous Oximation Reactions

Particle and Particle Systems Characterization, 36, 1900093.


MA Ogunwale, RJ Knipp, CN Evrard, LM Thompson, MH Nantz and X-A Fu

The Influence of Beta-Ammonium Substitution on the Reaction Kinetics of Aminooxy Condensations with Aldehydes and Ketones

ChemPhysChem, 20, 815-822.


R Ebule, S Mudshinge, MH Nantz, MS Mashuta, GB Hammond and B Xu

A 5+1 Protic Acid-Assisted aza-Pummerer Approach for Synthesis of                             

4-Chloropiperidines From Homoallylic Amines

Journal of Organic Chemistry, 84, 3249-3259.


2018


M Li, Q Li, MH Nantz and X-A Fu

Analysis of Carbonyl Compounds in Ambient air in by a Microreactor Approach

ACS Omega, 3, 6764 - 6769.


DJ Conklin, MA Ogunwale, Y Chen, MH Nantz, X-A Fu, DW Riggs, P Lorkiewicz, 

A Bhatnagar and S Srivastava

Electronic Cigarette-Generated Aldehydes: The Contribution of e-Liquid Components to their formation and the Use of Urinary Aldehyde Metabolites as Biomarkers of Exposure

Aerosol Science and Technology, 52, 1219 - 1232.


Z Xie, MVR Raju, AC Stewart, MH Nantz and X-A Fu

Imparting Sensitivity and Selectivity to a Gold Nanoparticle Chemiresistor through Thiol monolayer Functionalization for Sensing Acetone

RSC Advances, 8, 35618 - 35624.


P Deng, RM Higashi, AN Lane, RC Bruntz, RC Sun, MVR Raju, MH Nantz, Z Qi, TW-M Fan

Quantitative Profiling of Carbonyl Metabolites Directly in Crude Biological Extracts Using Chemoselective Tagging and nanoESI-FTMS

Analyst143, 311-322.



2017



MH Nantz and RJ Knipp

Nanoparticles for Drug Delivery

United States Patent No. 9,849,193

Issued: December 26, 2017


MA Ogunwale, Y Chen, WS Theis, MH Nantz, DJ Conklin and X-A Fu

Novel Method of Nicotine Quantification in Electronic Cigarette Liquids and Aerosols

Analytical Methods, 9, 4261-4266.


X-A Fu, MH Nantz and M Bousamra

Noninvasive Detection of Lung Cancer

United States Patent No. 9,638,965

Issued: May 2, 2017


(Textbook)  GS Zweifel, MH Nantz and P Somfai

Modern Organic Synthesis: An Introduction, 2nd Edition; Wiley: New York

ISBN: 978-1-119-08653-6 (416 pages).


MA Ogunwale, M Li, MVR Raju, Y Chen, MH Nantz, DJ Conklin and X-A Fu

Aldehyde Detection in Electronic Cigarette Aerosols

ACS Omega, 2, 1207-1214.



2016



SK Biladeau, WN Richmond, S Laulhé and MH Nantz

Isotopically Coded N-Methoxy Amide Reagents for GC-MS Profiling of Carbonyl Compounds via Mass Spectral Tag Generation

Analytical Methods8, 3704-3710.


MG O’Toole, PA Soucy, R Chauhan, MVR Raju, DN Patel, BM Nunn, MA Keynton, WD Ehringer, MH Nantz, RS Keynton and AS Gobin

Release-Modulated Antioxidant Activity of a Composite Curcumin-Chitosan Polymer

Biomacromolecules, 17, 1253-1260.



2015



K Gupta, SJ Mattingly, RJ Knipp, KA Afonin, M Viard, JT Bergman, M Stepler, MH Nantz, A Puri and BA Shapiro

Oxime Ether Lipids Containing Hydroxylated Head Groups Are More Superior siRNA Delivery Agents Than Their Nonhydroxylated Counterparts

Nanomedicine, 10, 2805-2828.


JG Hecker and MH Nantz

Methods and Models for Rapid, Widespread Delivery of Genetic Material to the CNS Using Non-Viral, Cationic Lipid-Mediated Vectors

United States Patent No. 9,149,543

Issued: October 6, 2015


SS Gori, MVR Raju, DA Fonseca, J Satyavolu, CT Burns and MH Nantz

Isolation of C5-Sugars from the Hemicellulose-Rich Hydrolyzate of Distillers Dried Grains

ACS Sustainable Chemistry & Engineering3, 2452-2457.


M Li, D Yang, G Brock, RJ Knipp, M Bousamra, MH Nantz and X-A Fu

Breath Carbonyl Compounds as Biomarkers of Lung Cancer

Lung Cancer, 90, 92-97.


RJ Knipp, M Li, X-A Fu and MH Nantz

A Versatile Probe for Chemoselective Capture and Analysis of Carbonyl Compounds in Exhaled Breath

Analytical Methods, 7, 6027-6033.


SJ Mattingly, MG O’Toole, KT James, GJ Clark and MH Nantz

Magnetic Nanoparticle–Supported Lipid Bilayers for Drug Delivery

Langmuir31, 3326-3332.


AN Lane, S Arumugam, PK Lorkiewicz, RM Higashi, S Laulhé, MH Nantz, HNB Moseley and TW-M Fan

Chemoselective Detection and Discrimination of Carbonyl-Containing Compounds in Metabolite Mixtures by 1H-Detected 15N Nuclear Magnetic Resonance

Magnetic Resonance in Chemistry53, 337-343.


ACG Grodzki, B Poola, N Pasupuleti, MH Nantz, PJ Lein and FA Gorin

A Novel Carboline Derivative Inhibits Nitric Oxide Formation in Macrophages Independent of Effects on TNF and IL-1 Expression

Journal of Pharmacology and Experimental Therapeutics352, 438-447.



2014



KA Kang and MH Nantz

Site Specific Fluorescence and Contrast Marker for Same

United States Patent No. 8,758,727

Issued: June 24, 2014


M Bousamra, E Schumer, M Li, RJ Knipp, MH Nantz, VH van Berkel and X-A Fu

Quantitative Analysis of Exhaled Carbonyl Compounds Distinguishes Benign From Malignant Pulmonary Disease

Journal of Thoracic and Cardiovascular Surgery, 1481074-1081.


SS Gori, P Lorkiewicz, DS Ehringer, AC Belshoff, RM Higashi, TW-M Fan and MH Nantz

Profiling Thiol Metabolites and Quantification of Cellular Glutathione using FT-ICR-MS Spectrometry

Analytical and Bioanalytical Chemistry406, 4371-4379.


RJ Knipp, R Estrada, P Sethu and MH Nantz

Thermally Induced Substrate Release Via Intramolecular Cyclizations of Amino Esters and Amino Carbonates

Tetrahedron, 70, 3422-3429.


X-A Fu, RM Higashi and MH Nantz

Pre-Concentrator and Method of Using the Same

United States Patent No.  8,663,581

Issued: March 4, 2014


X-A Fu, M Li, RJ Knipp, MH Nantz and M Bousamra

Noninvasive Detection of Lung Cancer Using Exhaled Breath

Cancer Medicine, 5, 174-181.



2013



FA Gorin and MH Nantz

Inhibitors of Intracellular Urokinase Plasminogen Activator and Methods of Use Thereof

United States Patent No.  8,546,322

Issued: October 1, 2013


S Laulhé, TE Geers, X Shi, X Zhang and MH Nantz

Electron Ionization-Induced Release of Coded Isotopic Reporter Ions in an m/z Zone of Minimal Interference for Quantifiable Multiplexed GC-MS Analyses

Analytical Methods, 5, 4701-4706.


M Li, S Biswas, MH Nantz, RM Higashi and X-A Fu

A Microfabricated Preconcentration Device for Breath Analysis 

Sensors and Actuators B: Chemical180, 130-136.



2012



SJ Mattingly, T Xu, MH Nantz, RM Higashi and TW-M Fan

A Carbonyl Capture Approach for Profiling Oxidized Metabolites in Cell Extracts

Metabolomics8, 989-996.


S Laulhé, SS Gori and MH Nantz

A Chemoselective, One-Pot Transformation of Aldehydes to Nitriles

Journal of Organic Chemistry77, 9334-9337.


S Laulhé, B Bogdanov, LM Johannes, O Gutierrez, GJ Harrison, DJ Tantillo,

X Zhang and MH Nantz

Fragmentation of Oxime and Silyl-Oxime Ether Odd-Electron Positive Ions by the McLafferty Rearrangement: New Insights on Structural Factors that Promote alpha-beta Fragmentation

Journal of Mass Spectrometry47, 676-686.


KA Kang, J Wang, MG O'Toole, MH Nantz, JD Moore, S Laulhé and S Achilefu

Sensitivity Enhancement of NIR Fluorescence Contrast Agent Utilizing Gold Nanoparticles

Advances in Experimental Medicine and Biology737, 285-291.


AP Massey, WR Harley, N Pasupuleti, FA Gorin and MH Nantz

2-Amidino Analogs of Glycine-Amiloride Conjugates: Inhibitors of Urokinase-type Plasminogen Activator

Bioorganic & Medicinal Chemistry Letters22, 2635-2639.


J Wang, JD Moore, S Laulhé, MH Nantz, S Achilefu and KA Kang

Fluorophore-Gold Nanoparticle Complex for Sensitive Optical Biosensing and Imaging

Nanotechnology23, 095501 (13pp).


M Li, S Biswas, MH Nantz, RM Higashi and X-A Fu

Preconcentration and Analysis of Trace Volatile Carbonyl Compounds

Analytical Chemistry84, 1288-1293.



2011



S Yellayi, B Hilliard, M Ghazanfar, A Tsingalia, MH Nantz, L Bollinger, F de Kok-Mercado and JG Hecker

A Single Intrathecal Injection of DNA and Asymmetric Cationic Lipid as Lipoplexes Ameliorates Experimental Autoimmune Encephalomyelitis

Molecular Pharmaceutics8, 1980-1984.


S Biswas, RJ Knipp, LE Gordon, GJ Clark and MH Nantz

Hydrophobic Oxime Ethers: A Versatile Class of pDNA and siRNA Transfection Lipids

ChemMedChem6, 2063-2069.


S Laulhé and MH Nantz

An Improved Preparation of O-Diphenylphosphinylhydroxylamine

Organic Preparations & Procedures, Int.43, 475-476.


X-A Fu, M Li, S Biswas, MH Nantz and RM Higashi 

A Novel Microreactor Approach for Analysis of Ketones and Aldehydes in Breath

Analyst136, 4662-4666.


J Wang, S Achilefu, MH Nantz and KA Kang 

Gold Nanoparticle-Fluorophore Complex for Conditionally Fluorescing Signal Mediator 

Analytica Chimica Acta695, 96-104.


S Biswas, LE Gordon, GJ Clark, and MH Nantz 

Click Assembly of Magnetic Nanovectors for Gene Delivery

Biomaterials32, 2683-2688.


J Wang, MG O'Toole, AP Massey, S Biswas, MH Nantz, S Achilefu and KA Kang

Highly Specific, NIR Fluorescent Contrast Agent with Emission Controlled by Gold Nanoparticles.  

Advances in Experimental Medicine and Biology701, 149-154.


FA Gorin and MH Nantz

Amino Acid and Peptide Conjugates of Amiloride and Methods of Use Thereof

United States Patent No. 7,863,415

Issued: January 4, 2011



2010



WR Harley, CL Floyd, TN Dunn, X-D Zhang, T-Y Chen, M Hegde, H Palandoken, MH Nantz, L Leon, KL Carraway III, BG Lyeth and FA Gorin

Dual Inhibition of Sodium-Mediated Proton and Calcium Transport Efflux Produces Caspase-Independent Cell Death in Malignant Gliomas

Brain Research, 1363, 159-169.


MH Nantz, CW Dicus, B Hilliard, S Yellayi, S Zou and JG Hecker

The Benefit of Hydrophobic Domain Asymmetry on the Efficacy of Transfection as Measured by In Vivo Imaging

Molecular Pharmaceutics, 7, 786-794.


S Zou, KA Scarfo, MH Nantz and JG Hecker

Lipid-Mediated Delivery of RNA is More Efficient Than Delivery of DNA in Non-Dividing Cells

International Journal of Pharmaceutics, 389, 232-243.


S Biswas, X Huang, WR Badger and MH Nantz

Nucleophilic Cationization Reagents

Tetrahendron Letters, 511727-1729.



2009



J Wang, MH Nantz, S Achilefu and KA Kang

FRET-Like Fluorophore-Nanoparticle Complex for Highly Specific Cancer Localization

Advances in Experimental Medicine and Biology662, 407-414.


(Textbook)  H Palandoken, MH Nantz and GS Zweifel

Problems in Organic Synthesis, WH Freeman & Co.: New York; ISBN: 1-4292-5592-7 (305 pages).


MT Nyunt, CW Dicus, Y.-Y Cui, MC Yappert, TR Huser, MH Nantz and J Wu

Physico-Chemical Characterization of Polylipid Nanoparticles for Gene Delivery to the Liver

Bioconjugate Chemistry, 20, 2047-2054.



2008



L Al-Nakkash, MF Springsteel, MJ Kurth and MH Nantz

Activation of CFTR by UCCF-029 and Genistein

Bioorganic & Medicinal Chemistry Letters18, 3874-3877.


JG Hecker, GO Berger, KA Scarfo, S Zou and MH Nantz

A Flexible Method for the Conjugation of Aminooxy Ligands to Pre-Formed Complexes  Nucleic Acids and Lipids

ChemMedChem3, 1356-1361.


B Poola, W Choung and MH Nantz

A  Mild, Catalyst-Free Synthesis of 2-Aminopyridines

Tetrahedron64, 10798-10801.


ES Hauck, S Zou, K Scarfo, MH Nantz and JG Hecker

Whole Animal In Vivo Imaging After Transient Nonviral Gene Delivery to the Rat Central Nervous System

Molecular Therapy16, 1857-1864.




2006



S-Q He, Y-H Zhang, SK Venugopal, CW Dicus, RV Perez, R Ramsamooj, MH Nantz, MA Zern and J Wu

Delivery of Antioxidative Enzyme Genes Protects Against Ischemia/Reperfusion-Induced Liver Injury in Mice

Liver Transplantation12, 1869-1879.


YF Suen, H Hope, MH Nantz, MJ Haddadin and MJ Kurth

Transannular Anti-Michael Addition: Formation of 4H-Pyrazolo[5,1-c]thiazines

Tetrahedron Letters, 47, 7893-7896.


CW Dicus and MH Nantz

Synthesis of a Heterobifunctional PEG Spacer Terminated with Aminooxy and Bromide Functionality

Synlett 17, 2821-2823.


R Rieger, PSC Leung, MR Jeddeloh, MJ Kurth, MH Nantz, KS Lam, D Barsky, AA Ansari, RL Coppel, IR Mackay and ME Gershwin

Identification of 2-Nonynoic Acid, a Cosmetic Component, as a Potential Trigger of Primary Biliary Cirrhosis

Journal of Autoimmunity, 27, 7-16.


(Textbook)  MH Nantz, H Palandoken and GS Zweifel

Solutions Manual for Modern Organic Synthesis, WH Freeman & Co.: New York; ISBN: 0-7167-7494-1 (218 pages).


(Textbook)  GS Zweifel and MH Nantz

Modern Organic Synthesis: An Introduction, WH Freeman & Co.: New York; ISBN: 0-7167-7266-3 (504 pages).


YF Suen, L Robins, B Yang, AS Verkman, MH Nantz and MJ Kurth

Sulfamoyl-4-oxoquinoline-3-carboxamides:  Novel Potentiators of Defective ΔF508-Cystic Fibrosis Transmembrane Conductance Regulator Chloride Channel Gating

Bioorganic & Medicinal Chemistry Letters, 16, 537-540.



2005



YF Suen, H Hope, MH Nantz, MJ Haddadin and MJ Kurth

A Novel Route to Fully Substituted 1H-Pyrazoles

Journal of Organic Chemistry, 70, 8468-8471.


H Palandoken, CM Bocian, MR McCombs and MH Nantz

A Facile Synthesis of (tert-Alkoxy)amines

Tetrahedron Letters, 46, 6667-6669.


N Pedemonte, ND Sonawane, A Taddei, J Hu, O Zegarra-Moran, YF Suen, L Robins, CW Dicus, D Willenbring, MH Nantz, MJ Kurth, LJV Galietta and AS Verkman  Phenylglycine and Sulfonamide Correctors of Defective ΔF508- and G551D-CFTR Chloride-Channel Gating

Molecular Pharmacology, 67, 1797-1807.


K Amano, PSC Leung, R Rieger, C Quan, X Wang, J Marik, YF Suen, MJ Kurth, MH Nantz, AA Ansari, KS Lam, M Zeniya, E Matsuura, RL Coppel and ME Gershwin Chemical Xenobiotics and Mitochondrial Autoantigens in Primary Biliary Cirrhosis:  Identification of Antibodies against a Common Environmental, Cosmetic, and Food Additive, 2-Octynoic Acid

Journal of Immunology, 174, 5874-5883.


CW Dicus, D Willenbring and MH Nantz

Synthesis of 13C1-Pinonaldehyde

Journal of Labelled Compounds and Radiopharmaceuticals, 48, 223-229.


H Palandoken, K By, M Hegde, WR Harley, FA Gorin and MH Nantz

Amiloride Peptide Conjugates: Prodrugs for Sodium-Proton Exchange Inhibition

Journal of Pharmacology and Experimental Therapuetics, 312, 961-967.



2004



JT Sanderson, J Hordijk, MS Denison, MF Springsteel, MH Nantz and M van den Berg

Induction and Inhibition of Aromatase (CYP19) Activity by Natural and Synthetic Flavonoid Compounds in H295R Human Adrenocortical Carcinoma Cells

Toxicological Sciences, 82, 70-79.


K Amano, PSC Leung, Q Xu, J Marik, C Quan, MJ Kurth, MH Nantz, AA Ansari, KS Lam, M Zeniya, RL Coppel and ME Gershwin

Xenobiotic-Induced Loss of Tolerance in Rabbits to the Mitochondrial Autoantigen of Primary Biliary Cirrhosis is Reversible

Journal of Immunology, 172, 6444-6452.


B Zhao, S Nagy, J Rogers, MH Nantz, MJ Kurth, MF Springsteel and MS Denison

Identification and Analysis of Novel Flavonoid Agonists and Antagonists for the

Ah and Estrogen Receptor

Organohalogen Compounds, 66,2960-2965.


J Wu, L Liu, RD Yen, A Catana, MH Nantz and MA Zern

Liposome-Mediated Extracellular Superoxide Dismutase Gene Delivery Protects Against Acute Liver Injury in Mice

Hetaptology, 40, 195-204.


K By and MH Nantz

Dioxazocinium Ortho Esters: A Class of Highly pH-Vulnerable Amphiphiles 

Angewandte Chemie International Ed., 43, 1117-1120.



2003



SFA Bruggraber, PSC Leung, K Amano, C Quan, MJ Kurth, MH Nantz, GD Benson, J Van de Water, V Luketic, TE Roche, AA Ansari, RL Coppel and ME Gershwin

Autoreactivity to Lipoate and a Conjugated Form of Lipoate in Primary Biliary Cirrhosis

Gastroenterology, 125, 1705-1713.


C Selmi, DL Balkwill, P Invernizzi, AA Ansari, RL Coppel, M Podda, PS Leung, TP

Kenny, J Van de Water, MH Nantz, MJ Kurth and ME Gershwin

Patients with Primary Biliary Cirrhosis React Against a Ubiquitous Xenobiotic

Metabolizing Bacterium

Hepatology, 38, 1250-1257.


DS Baston, SR Nagy, MH Nantz, MJ Kurth, MF Springsteel and MS  Denison

Identification of Novel Agonists and Antagonists of the Ah Receptor Signal Transduction Pathway

Organohalogen Compounds, 65, 142-145.


D-H Han, B Zhao, DS Baston, MF Springsteel, MJ Kurth, MH Nantz and MS Denison 

Identification and Characterization of Novel Flavone Agonists of the Ah Receptor

Organohalogen Compounds, 65, 126-129.


B Zhao, SR Nagy, DS Baston, D-H Han, MH Nantz, MJ Kurth, MF Springsteel and MS

Denison

Screening and Analysis of Novel Naphthoflavone Ligands for the Ah Receptor

Organohalogen Compounds, 65, 102-105.


PA Kelly, GO Berger, JK Wyatt and MH Nantz

Synthesis of [Ethylene-1-(h5-4, 5, 6, 7-tetrahydro-1-indenyl)-2-(h5-4’, 5’, 6’, 7’-tetrahydro-2’-indenyl)] titanium Dichloride, the Elusive Isomer of the Brintzinger-type ansa-Titanocenes

Journal of Organic Chemistry, 68, 8447-8452.


MF Springsteel, LJV Galietta, T Ma, K By, GO Berger, H Yang, CW Dicus, W Choung, C Quan, AA Shelat, RK Guy, AS Verkman, MJ Kurth and MH Nantz

Benzoflavone Activators of the Cystic Fibrosis Transmembrane Conductance Regulator: Towards a Pharmacophore Model for the Nucleotide-Binding Domain

Bioorganic & Medicinal Chemistry, 11, 4113-4120.


E Caci, C Folli, O Zegarra-Moran, T Ma, MF Springsteel, RE Sammelson, MH Nantz, MJ Kurth, AS Verkman and LJV Galietta

CFTR Activation in Human Bronchial Epithelial Cells By Novel Benzoflavone and Benzimidazolone Compounds Identified By High-Throughput Screening

American Journal of Physiology — Lung Cellular and Molecular Physiology, 285, L180-L188.


PSC Leung, C Quan, O Park, J Van de Water, MJ Kurth, MH Nantz, AA Ansari, RL Coppel, KS Lam and ME Gershwin

Immunization With a Xenobiotic 6-Bromohexanoate Bovine Serum Albumin Conjugate Induces Antimitochondrial Antibodies

Journal of Immunology170, 5326-5332.


CW Dicus, KJ Burnham, MJ Charles and MH Nantz

Synthesis of 13C3-Hydroxyacetone

Journal of Labelled Compounds and Radiopharmaceuticals, 46, 793-798.


EJ Niedzinski, DC Olson, YJ Chen, JA Udove, MH Nantz, HC Tseng, JL Bolaffi and MJ Bennett

Zinc Enhancement of Nonviral Salivary Gland Transfection

Molecular Therapy, 7, 396-400.


DM Anderson, LL Hall, AR Ayyalapu, VR Irion, MH Nantz and JG Hecker

Stability of mRNA/Cationic Lipid Lipoplexes in Human and Rat Cerebro-spinal Fluid:  Methods and Evidence for Non-Viral mRNA Gene Delivery to the Central Nervous System

Human Gene Therapy, 14, 191-202.


MR Lashley, CW Dicus, K Brown and MH Nantz

Synthesis of a-Hydroxytamoxifen and Its 4-Hydroxy Analog

Organic Preparations & Procedures International, 35, 231-238.


L Liu, MA Zern, ME Lizarzaburu, MH Nantz and J Wu

Poly(Cationic Lipid)-Mediated in vivo Gene Delivery to Mouse Liver

Gene Therapy, 10, 180-187.



2002



Bennett, M. J.; Nantz, M. H.; Rothman, S.
Method for Nucleic Acid Transfection of Cells
United States Patent No. 6,372,722
Issued: April 16, 2002


MM Olmstead, K By and MH Nantz

A Long Thin Molecule, 2,6-Dimethyl-6 tetradecyl-2-tetradecyloxy-1,3,6

dioxazocan-6 ium Iodide

Acta Crystallographica E58, o1323-o1324.


MR Lashley, EJ Niedzinski, JM Rogers, MS Denison and MH Nantz

Synthesis and Estrogen Receptor Affinity of a 4-Hydroxytamoxifen–Labeled Ligand for Diagnostic Imaging

Bioorganic & Medicinal Chemistry, 10, 4075-4082.


EJ Niedzinski, SK Fujii, ME Lizarzaburu, JG Hecker and MH Nantz

A Versatile Linker for Non-Toxic Polyamine-Mediated DNA Transfection.

Molecular Therapy, 6, 279-286.


J Wu, MH Nantz and MA Zern

Targeting Hepatocytes for Drug and Gene Delivery: Emerging Novel Approaches and Applications.

Fontiers in Bioscience, 7, D717-D725.



2001



Nantz, M. H.; Zhu, J.

Ortho Ester Lipids

United States Patent No.  6,200,599

Issued: March 13, 2001


Nantz, M. H.; Aberle, A. M.
Pentaerythritol Lipid Derivatives  (Divisional)
United States Patent No.  6,316,421
Issued: November 13, 2001


SA Long, C Quan, J Van de Water, MH Nantz, MJ Kurth, D Barsky, ME Colvin, KS Lam, RL Coppel, A Ansari and ME Gershwin

Immunoreactivity of Organic Mimeotopes of the E2 Component of Pyruvate Dehydrogenase: Connecting Xenobiotics with Primary Biliary Cirrhosis

Journal of Immunology, 167, 2956-2963.


KA Campbell, MR Lashley, JK Wyatt, MH Nantz and RD Britt

Dual-Mode EPR Study of Mn(III) Salen and the Mn(III) Salen-Catalyzed Epoxidation of cis-b-Methylstyrene

Journal of the American Chemical Society, 123, 5710-5719.


LVJ Galietta, MF Springsteel, M Eda, EJ Niedzinski, K By, MJ Haddadin, MJ Kurth, MH Nantz and AS Verkman

Novel CFTR Chloride Channel Activators Identified By Screening of Combinatorial Libraries Based on Flavone and Benzoquinolizinium Lead Compounds

Journal of Biological Chemistry, 276, 19723-19728.


EJ Niedzinski, MR Lashley and MH Nantz

On the Synthesis and Reactivity of 1-Benzyl-2-arylquinoline-4-thiones

Heterocycles, 55, 623-627.


C Alonso, MM Olmstead, MH Nantz and MJ Kurth

Competitive Intramolecular Nucleophilic Aromatic Substitution: A New Route to Coumarins

Journal of the Chemical Society, Chemical Communications, 639-640.


J Wu, ME Lizarzaburu, MJ Kurth, H Wege, MA Zern and MH Nantz

Cationic Lipid Polymerization as a Novel Approach to Improve Lipoplex Stability, Toxicity and Transfection Activity

Bioconjugate Chemistry, 12, 251-257.


K By, PA Kelly, MJ Kurth, MM Olmstead and MH Nantz

Synthesis of a C(4)-C(9) Eleutheside Template From D-Glucal

Tetrahedron, 57, 1183-1187.



2000



Nantz, M. H.; Aberle, A. M.

Pentaerythritol Lipid Derivatives

United States Patent No.  6,043,390

Issued: March 28, 2000


B Illek, ME Lizarzaburu, V Lee, MH Nantz, MJ Kurth and H Fischer

Structural Determinants for Activation and Block of CFTR-Mediated Chloride Currents by Apigenin

American Journal of Physiology and Cell Physiology, 279, 1838-1846.


M Eda, MJ Kurth and MH Nantz

The Solid-Phase Zincke Reaction: Preparation of w-Hydroxy Pyridinium Salts in the Search for CFTR Activation

Journal of Organic Chemistry, 65, 5131-5135.


EJ Niedzinski, MJ Bennett, DC Olson and MH Nantz

Gastroprotection of DNA with a Synthetic Cholic Acid Analog

Lipids, 35, 721-727.


C Alonso, MH Nantz and MJ Kurth

b-Dimethylphenylsilylethyl Esters: A Linker for Solid-Phase Chemistry

Tetrahedron Letters, 41, 5617-5622.


P Kim, MM Olmstead, MH Nantz and MJ Kurth

Knoevenagel Condensations of b-Hemiacetyl Esters

Tetrahedron Letters, 41, 4029-4032.


P Kim, MH Nantz, MJ Kurth and MM Olmstead

Intramolecular Diels-Alder Reactions of Decatrienoates: Remote Stereocontrol and Conformational Activation

Organic Letters, 2, 1831-1834.


MR Lashley and MH Nantz

Synthesis of Lipidic Tamoxifen

Tetrahedron Letters, 41, 3295-3298.


J Zhu, RJ Munn and MH Nantz

Self-Cleaving Ortho Ester Lipids:  A New Class of pH-Vulnerable Amphiphiles

Journal of the American Chemical Society, 122, 2645-2646.



1999



Nantz, M. H.; Bennett, M. J.; Balasubramaniam, R. P.

Polyfunctional Cationic Cytofectins

United States Patent No.  5,869,715

Issued: February 9, 1999


Nantz, M. H.; Bennett, M. J.; Malone, R. W.
Cationic Transport Reagents (CIP)
United States Patent No.  5,892,071
Issued: April 6, 1999


Nantz, M. H.; Bennett, M. J.; Balasubramaniam, R. P.; Aberle, A. M.; Malone, R. W.
Polyfunctional Cationic Cytofectins, Formulations and Methods for Generating Active Cytofectin: Polynucleotide Transfection Complexes
United States Patent No.  5,925,623
Issued: July 20, 1999


Nantz, M. H.; Bennett, M. J.; Balasubramaniam, R. P.; Aberle, A. M.; Malone, R. W.
Polyfunctional Cationic Cytofectins, Formulations and Methods for Generating Active Cytofectin: Polynucleotide Transfection Complexes (CIP)
United States Patent No.  5,824,812
Issued: October 20, 1998


Palandoken, H.; Wyatt, J. K.; Hitchcock, S. R.; Olmstead, M. M.; Nantz, M. H.
Reductive Dehydroxy Coupling of 2-(Hydroxymethyl)indenes to Prepare Ethylene-Bridged Bis(2-indenyl) ansa-Titanocenes
Journal of Organometallic Chemistry, 579, 338-347.


Moss, D. K.; Spence, J. D.; Nantz, M. H.
The Effects of Propargylic Substitution and Annelation on the Cycloaromatization of a Bicyclo[7.3.1] Enediyne
Journal of Organic Chemistry, 64, 4339-4343.


Lizarzaburu, M. E.; Jones, R. M.; Nantz, M. H.; Kurth, M. J.
Mutligram Synthesis of Dimyristoyl Pentaerythritol
Organic Preparations and Procedures Intl., 31, 440-442.


Lizarzaburu, M. E.; Kurth, M. J.; Nantz, M. H.
A Versatile Synthesis of Tetraester Polyamine Lipids for Gene Transfection
Tetrahedron Letters, 408985-8988.



1998



Nantz, M. H.; Bennett, M. J.; Malone, R. W.

Cationic Transport Reagents (Divisional Application)

United States Patent No.  5,744,625

Issued: April 28, 1998


Nantz, M. H.; Moss, D. K.; Spence, J. D.; Olmstead, M. M.
Actuating Cycloaromatization of a Bicyclo[7.3.1] Enediyne by Annelation, an Example of Inverse Dependence on Bridge Hybridization
Angewandte Chemie, Intl. Ed., 37, 470-473.


Aberle, A. M.; Tablin, F.; Zhu, J.; Walker, N. J.; Gruenert, D. C.; Nantz, M. H.
A Novel Tetraester Construct That Reduces Cationic Lipid-Associated Cytotoxicity.  Implications for the Onset of Cytotoxicity
Biochemistry, 37, 6533-6540.


Moss, D. K.; Olmstead, M. M.; Nantz, M. H.
Aluminum-Mediated 1,2-Alkyl Migration Resulting From Hydrocyanation of an alpha-Epoxy Ketone
Journal of Organic Chemistry, 63, 5259-5261.


Nantz, M. H.; Li, L.; Zhu, J.; Aho-Sharon, K. L.; Lim, D.; Erickson, K. L.
Inductive Electron-Withdrawal From Ammonium Ion Headgroups of Cationic Lipids and the Influence on DNA Transfection
Biochim. Biophys. Acta, 1394, 219-223.



1997



Balasubramaniam, R. P.; Moss, D. K.; Wyatt, J. K.; Spence, J. D.; Gee, A. H.; Nantz, M. H.

Quaternary Centers Via Regioselective Methylation-Ring Opening of 3,3-Disubstituted 2,3-Epoxy Alcohols.  Synthesis of Chiral Quaternary Fragments for Assembly of Briaran Diterpenes

Tetrahedron, 53, 7429-7444.


Wisner, E. R.; Aho-Sharon, K. L.; Bennett, M. J.; Penn, S. G.; Lebrilla, C. B.; Nantz, M. H.
A Modular Lymphographic Magnetic Resonance Imaging Contrast Agent:  Contrast Enhancement with DNA Transfection Potential
Journal of Medicinal Chemistry, 40, 3992-3996.


Bennett, M. J.; Aberle, A. M.; Balasubramaniam, R. P.; Malone, J. G.; Malone, R. W.; Nantz, M. H.
Cationic Lipid-Mediated Gene Delivery to Murine Lung: Correlation of Lipid Hydration With In Vivo Transfection Activity
Journal of Medicinal Chemistry, 40, 4069-4078.



1996



Nantz, M. H.; Bennett, M. J.; Malone, R. W.

Cationic Transport Reagents

United States Patent No.  5,527,928

Issued: June 18, 1996


Aberle, A. M.; Bennett, M. J.; Malone, R. W.; Nantz, M. H.
The Counterion Influence on Cationic Lipid-Mediated Transfection of Plasmid DNA
Biochim. Biophys. Acta, 1299, 281-283.


Balasubramaniam, R. P.; Bennett, M. J.; Aberle, A. M.; Malone, J. G.; Nantz, M. H.; Malone, R. W.
Structural and Functional Analysis of Cationic Transfection Lipids: The Hydrophobic Domain
Gene Therapy, 3, 163-172.


Spence, J. D.; Wyatt, J. K.; Bender, D. M.; Moss, D. K.; Nantz, M. H.
Stereogenic Propargylic Centers Via Base-Mediated Terminal Allene Isomerization
Journal of Organic Chemistry, 61, 4014-4021.


Olmstead, M. M.; Hitchcock, S. R.; Nantz, M. H.
Cyclohexane-Linked Indenyl Rings in 5,8-Bis(trimethylsilyl)-6,7-dihydroindeno[2,1c]-fluorene
Acta Crystallographica, C52, 1523.


Bennett, M. J.; Aberle, A. M.; Balasubramaniam, R. P.; Malone, J. G.; Nantz, M. H.; Malone, R. W.
Considerations for the Design of Improved Cationic Amphiphile-Based Transfection Reagents
Journal of Liposome Research, 6545.


Palandoken, H.; McMillen, W. T.; Nantz, M. H.
An Improved Synthesis of 2-(Hydroxymethyl)indene
Organic Preparations and Procedures Intl., 28, 702-704.


Freedland, S. J.; Malone, R. W.; Borchers, H. M.; Zadourian, Z.; Malone, J. G.; Bennett, M. J.; Nantz, M. H.; Juan-Hua, L.; Gummerlock, P. H.; Erickson, K. L.
Toxicity of Cationic Lipid-Ribozyme in Human Prostate Tumor Cells Can Mimic Ribozyme Activity.
Biochemical and Molecular Medicine, 59, 144-153.



1995



Bennett, M. J.; Nantz, M. H.; Balasubramaniam, R. P.; Gruenert, D. C.; Malone, R. W.

Cholesterol Enhances Cationic Liposome-Mediated DNA Transfection of Human Respiratory Epithelial Cells

Bioscience Reports, 1547.


Bennett, M. J.; Malone, R. W.; Nantz, M. H.
A Flexible Approach to Synthetic Lipid Ammonium Salts for Polynucleotide Transfection
Tetrahedron Letters, 36: 2207-2210.


Spence, J. D.; Lowrie, L. E.; Nantz, M. H.
Cyclobutene Formation Accompanying an Intramolecular Lewis Acid-Promoted Spirocyclization of a Propargylic Silane
Tetrahedron Letters, 36: 5499-5502.


Hitchcock, S. R.; Situ, J. J.; Covel, J. A.; Olmstead, M. M.; Nantz, M. H.
Synthesis of ansa-Titanocenes From 1,2-Bis(2-indenyl)ethane and Structural Comparisons in the Catalytic Epoxidation of Unfunctionalized Alkenes
Organometallics, 14: 3732-3740.



1994 - 1984



Parkin, S.; Hitchcock, S. R.; Hope, H.; Nantz, M. H.

2,2'-Ethylenebis(indenyl)TiCl2

Acta Crystallographica, C50, 169-171 (1994).


Nantz, M. H.; Bender, D. M.; Janaki, S.
A Convenient Terminal Allene Synthesis from Propargylic Acetates
Synthesis, 577-578 (1993).


Sutton, S. C.; Nantz, M. H.; Parkin, S.
Synthesis of ansa-Titanocenes via a Double-Skattebøl Rearrangement
Organometallics, 12, 2248-2257 (1993).


Nantz, M. H.; Hitchcock, S. R.; Sutton, S. C.; Smith, M. D.
A Disulfone-Based Approach to ansa-Titanocenes: Synthesis of (Ethylenebis(2-indenyl))titanium Dichloride
Organometallics, 12, 5012-5015 (1993).


Sutton, S. C.; Nantz, M. H.; Hitchcock, S. R.
Preparation and Optical Resolution of DL-2,3-Dimethylsuccinic Acid
Organic Preparations and Procedures Intl., 24, 39-43 (1992).


Nantz, M. H.; Lee, D. A.; Bender, D. M.; Roohi, A. H.
An Enantioselective Synthesis of Vicinal Diamines
Journal of Organic Chemistry, 57, 6653-6657 (1992).


Kageyama, M.; Tamura, T.; Nantz, M. H.; Roberts, J. C.; Somfai, P.; Whritenour, D. C.; Masamune, S.
Synthesis of Bryostatin 7
Journal of the American Chemical Society, 112, 7407-7408 (1990).


Pan, Y.; Hutchinson, D. K.; Nantz, M. H.; Fuchs, P. L.
SN2' Additions of Cuprates to Sulfone and Ester Polarized Cyclopentenylic Systems
Tetrahedron, 45, 467-478 (1989).


Blanchette, M. A.; Malamus, M. S.; Nantz, M. H.; Roberts, J. C.; Somfai, P.; Whritenour, D. C.; Masamune, S.; Kageyama, M.; Tamura, T.
Synthesis of Bryostatins.  1. Construction of the C(1)-C(16) Fragment
Journal of Organic Chemistry, 54, 2817-2825 (1989).


Duplantier, A. J.; Nantz, M. H.; Roberts, J. C.; Short, R. P.; Somfai, P.; Masamune, S.
Triple Asymmetric Synthesis for Fragment Assembly:  Validity of Approximate Multiplicativity of the Three Diastereofacial Selectivities
Tetrahedron Letters, 30, 7357-7360 (1989).


Nantz, M. H.; Fuchs, P. L.
Efficient Generation and Use of 3-Carboalkoxycyclopentan-dienone as a Diels-Alder Dienophile
Journal of Organic Chemistry, 52, 5298-5299 (1987).


Nantz, M. H.; Radisson, X.; Fuchs, P. L.
Efficient 4 +1 Syntheses of Highly Functionalized Cyclopentenes
Synthetic Communications, 17, 55-69 (1987).


Nantz, M. H.; Fuchs, P. L.
Cycloaromatization Reactions of Methyl 4-Carbomethoxy-5-methoxy-penta-2,4-dienoate
Synthetic Communications, 17, 761-771 (1987).


Frisbee, A. R.; Nantz, M. H.; Kramer, G. W.; Fuchs, P. L.
Robotic Orchestration of Organic Reactions Yield Optimization via an Automated System with Operator-Specified Reaction Sequences

Journal of the American Chemical Society, 106, 7143-7145 (1984).

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