Ongoing Research



We seek to develop reagents and methods for chemoselective derivatization of complex biological mixtures, such as exhaled breath or tissue extracts.  Our work toward identifying markers of lung cancer, for example, features a silicon microreactor containing thousands of micropillars coated with an aminooxy reagent that selectively captures carbonyl metabolites for quantification. 

               

                Lung Cancer 201590, 92

                Analytical Methods 20157, 6027

                Analytical & Bioanalytical Chemistry 2014406, 4371 

                Cancer Medicine 20143, 174

                Sensors and Actuators 2013180, 130

                Metabolomics 20128, 989 


We also are interested in developing magnetic nanoparticles to serve as triggerable carriers of small molecules.  This work aims to exploit application of an alternating magnetic field to induce local hyperthermia that, in turn, powers small molecule release.  Research efforts here are devoted to preparation of functionalized lipid-, silica- and gold-coated iron oxide nanoparticles.

               

                Langmuir 201531, 3326

                Tetrahedron 201470, 3422


In the course of preparing targets or fitting nanoparticles with custom linkers, we often uncover unexpected reactivity that leads us to pursue synthetic projects only tangentially related to the two principal thrusts described above.  For example, we recently solved how to selectively isolate xylose from distillers dried grains, how to prepare oxime ether lipids for optimal siRNA delivery, how to use mass spectral fragmentations as a tool for quantifying analytes in multiplexed samples, and how to convert aldehydes to nitriles in one pot.  Organic synthesis is a joy!


                ACS Sustainable Chemistry & Engineering 20153, 2452

                Nanomedicine 201510, 2805

                Analytical Methods 20135, 4701

                Journal of Organic Chemistry 201277, 9334




Samples of our past work….

2210 S. Brook Street, Louisville, KY 40292 (502) 852-3518